Pheniramine maleate

Research use only, not for human use.

Pheniramine Maleate is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria.

Pheniramine Maleate is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria.(In Vitro):Pheniramine maleate inhibits CYP2D6, the specific P450-isozymes, to delay metabolic time and prolong antihistaminic effects.Pheniramine maleate regulates cellular Ca2+ transmembrane action, and inhibits Ca2+ influx into BC3H-1 cells by inhibiting histamine with an IC50 value of 1.01 mM.Pheniramine maleate (0.5, 1.0 mM; 24 h) induces cell apoptosis in human T-cell acute lymphoblastic leukemia cell lines.Pheniramine maleate (1 μM-1 mM; 12-48 h) inhibits cell proliferation in a time-dependent manner and shows inhibitory concentration IC50s of 550 μM (CCRF-CEM cells) and 420 μM (Jurkat cells), respectively.(In Vivo):Pheniramine maleate (1.75 μM; i.t.) exerts local anesthesia effect and results spinal block in rats.

Pheniramine maleate inhibits CYP2D6, the specific P450-isozymes, to delay metabolic time and prolong antihistaminic effects.Pheniramine maleate regulates cellular Ca2+ transmembrane action, and inhibits Ca2+ influx into BC3H-1 cells by inhibiting histamine with an IC50 value of 1.01 mM.Pheniramine maleate (0.5, 1.0 mM; 24 h) induces cell apoptosis in human T-cell acute lymphoblastic leukemia cell lines.Pheniramine maleate (1 μM-1 mM; 12-48 h) inhibits cell proliferation in a time-dependent manner and shows inhibitory concentration IC50s of 550 μM (CCRF-CEM cells) and 420 μM (Jurkat cells), respectively. They are for reference only.Cell Viability AssayCell Line:Human T-cell acute lymphoblastic leukemia cell lines: CCRF-CEM and Jurkat ALL Concentration:0.5, 1.0 mM Incubation Time:24 hours Result:Induced cells apoptosis with chromatin condenses and marginalizes, and nuclear debris spreaded into the cytoplasm.Cell Viability AssayCell Line:Human T-cell acute lymphoblastic leukemia cell lines: CCRF-CEM and Jurkat ALL Concentration:1 μM-1 mM Incubation Time:12, 24, 48 hours Result:Inhibited cell proliferation and survival in a time- and dose-dependent manner.

Pheniramine maleate (1.75 μM; i.t.) exerts local anesthesia effect and results spinal block in rats. Animal Model:Sprague–Dawley rats (300-350 g; male) Dosage:0.30, 0.60, 0.90, 1.50, 1.75 μM Administration:Intrathecal injection; one time Result:Resulted the spinal block and displayed dose-dependent effect.Showed 100% blockades in motor function, proprioception, and nociception, with full recoveryduration of action about 41, 56, and 88 min, respectively, at 1.75 μM.

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Endocrinology/Hormones

5-HT Receptor

HT

Inflammation/Immunology

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132-20-7

356.42

C16H20N2·C4H4O4

>98% (HPLC)

Ethanol: 71 mg/mL (199.2 mM); Water: 71 mg/mL (199.2 mM); DMSO: 71 mg/mL (199.2 mM)

CN(C)CCC(C1=CC=CC=C1)C2=CC=CC=N2.C(=C\C(=O)O)\C(=O)O

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(-20℃)

With Ice Pack

≥ 2 years